Grant: Operating Grant
Institut de recherches cliniques de Montréal
$829,560.00
Immune regulation by SAP, the X-linked lymphoproliferative (XLP) gene product
FY 2009-10
Summary
SAP is a small protein that resides inside the cell and is termed "adaptor". It is present only in cells of the immune system. SAP is mutated in a human immunodeficiency named X-linked lymphoproliferative (XLP) disease, which is characterized by an abnormal ability to fight certain viruses and immune cell cancers. Over the past years, we uncovered how SAP regulates the normal immune system. We also provided insights into the mechanisms by which SAP mutations can lead to immunodeficiencies and cancers. Lastly, we found that SAP may be involved in the unfortunate capacity of some humans to develop auto-immune diseases like rheumatoid arthritis. In the current proposal, we will continue to study the role and regulation of SAP. The results of these studies will not only augment our comprehension of the normal immune system, but will also help elucidate and, perhaps, treat certain human diseases.
Department
Program
Operating Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
198604
Name
Veillette André
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
Immune regulation by SAP, the X-linked lymphoproliferative (XLP) gene product
Programtype2
Operating Grants
Orgnameinp2
Institut de recherches cliniques de Montréal
Cihramount2
$829,560
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Adaptors; Auto-Immunity; Immunodeficiency; Kinases; Receptors; Signal Transduction
Abstract
SAP is a small protein that resides inside the cell and is termed "adaptor". It is present only in cells of the immune system. SAP is mutated in a human immunodeficiency named X-linked lymphoproliferative (XLP) disease, which is characterized by an abnormal ability to fight certain viruses and immune cell cancers. Over the past years, we uncovered how SAP regulates the normal immune system. We also provided insights into the mechanisms by which SAP mutations can lead to immunodeficiencies and cancers. Lastly, we found that SAP may be involved in the unfortunate capacity of some humans to develop auto-immune diseases like rheumatoid arthritis. In the current proposal, we will continue to study the role and regulation of SAP. The results of these studies will not only augment our comprehension of the normal immune system, but will also help elucidate and, perhaps, treat certain human diseases.
Competitiondate
201003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Veillette, André
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $829,560~ $0~
