Grant: Operating Grant: Fall 2008 Priority Announcement (IMHA)
University of British Columbia
$100,000.00
Regulation of the balance between repair and regeneration in skeletal muscle
FY 2008-09
Summary
Damaged tissues can undergo repair or regeneration. Repair leads to the replacement of the lost tissue with non-functional components, usually fibrous scar or fat infiltration. Regeneration is a process at the endpoint of which the lost tissue is returned to full functionality. It is unclear what determines whether one of the other prevails following damage. Here, we propose to study the stem/progenitor cells involved in these processes and the mechanisms that regulate their function. We will use skeletal muscle as a model system as scarring and fat infiltration are significant clinical problems in this tissue, but we expect similar mechanisms to be at play in other tissues.
Department
Program
Operating Grant: Fall 2008 Priority Announcement (IMHA)
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
179195
Name
Rossi Fabio M
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Developmental Biology
Projecttitle
Regulation of the balance between repair and regeneration in skeletal muscle
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Operating Grant: Fall 2008 Priority Announcement (IMHA)
Keyworddelim
Fibro/Adipogenic Precursors; Muscle Degenerative Disease; Myogenic Precursors; Prospective Purification; Regeneration Vs Repair; Systems Biology
Abstract
Damaged tissues can undergo repair or regeneration. Repair leads to the replacement of the lost tissue with non-functional components, usually fibrous scar or fat infiltration. Regeneration is a process at the endpoint of which the lost tissue is returned to full functionality. It is unclear what determines whether one of the other prevails following damage. Here, we propose to study the stem/progenitor cells involved in these processes and the mechanisms that regulate their function. We will use skeletal muscle as a model system as scarring and fat infiltration are significant clinical problems in this tissue, but we expect similar mechanisms to be at play in other tissues.
Competitiondate
200809
Approvedterm2
1 yr 0 mth
Pinamesdelim
Rossi, Fabio M
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
