Grant: Project Grant
University of British Columbia
$1,170,450.00
Setting the homeostatic inflammatory environment: role of the Tak1-NFkb pathway in mesenchymal stromal cells.
FY 2025-26
Summary
At least two types of inflammation exist: type 1 inflammation is generally associated with controlling infections or clearing debris from damage, while type 2 inflammation is active in allergy but also associated with damage repair. Whether someone is more prone to one or the other type of response can influence how they react to damage. Here we propose to study the mechanisms that makes the resting inflammatory environment biased towards one type of response, and how modulating it affects the response to tissue damage. Understanding these mechanisms may reveal strategies to improve the outcome of a wide range of afflictions.
Department
Program
Project Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
534487
Name
Rossi Fabio M
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology
Projecttitle
Setting the homeostatic inflammatory environment: role of the Tak1-NFkb pathway in mesenchymal stromal cells.
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$1,170,450
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Fibroblasts; Innate Immune Cells; Stromal Cells
Abstract
At least two types of inflammation exist: type 1 inflammation is generally associated with controlling infections or clearing debris from damage, while type 2 inflammation is active in allergy but also associated with damage repair. Whether someone is more prone to one or the other type of response can influence how they react to damage. Here we propose to study the mechanisms that makes the resting inflammatory environment biased towards one type of response, and how modulating it affects the response to tissue damage. Understanding these mechanisms may reveal strategies to improve the outcome of a wide range of afflictions.
Competitiondate
202509
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Rossi, Fabio M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,170,450~ $0~
