Grant: Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
University of British Columbia
$105,000.00
HIV immune escape mutations as predictors of abacavir hypersensitivity, and probes for HIV pathogenesis and evolution
FY 2009-10
Summary
Our aim is to investigate the evolution of HIV in response to the human immune system and in response to HIV drug therapy. This will focus on three main areas:
(1) Markers in HIV are associated with genetic factors in the host's immune system. One of these markers is highly associated with a serious reaction to an HIV medication called abacavir, and its presence or absence is reflected in HIV's genes. Following these changes in HIV's genes give us an additional way to predict who will have serious side-effects from abacavir.
(2) We will be able to monitor how HIV evolves over time in response to this immune pressure, and how this changes with HIV treatment. The extent this evolution will give us insight into how the immune system works.
(3) We also propose to use a new, highly sensitive DNA sequencing method that has just been developed to follow these genetic changes in HIV, even when they are emerging at low levels within a patient's viral population.
Department
Program
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
206223
Name
Swenson Luke C
Region
British Columbia
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Doctoral Research Awards - A
Projecttitle
HIV immune escape mutations as predictors of abacavir hypersensitivity, and probes for HIV pathogenesis and evolution
Programtype2
Studentship Programs
Orgnameinp2
University of British Columbia
Cihramount2
$105,000
Cihrequipment2
$0
Programname2
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Keyworddelim
Abacavir Hypersensitivity; Antiretroviral Therapy; Human Immunodeficiency Virus (Hiv); Human Leukocyte Antigen (Hla); Immune Escape; Pathogenesis; Ultra-Deep Pyrosequencing
Abstract
Our aim is to investigate the evolution of HIV in response to the human immune system and in response to HIV drug therapy. This will focus on three main areas:
(1) Markers in HIV are associated with genetic factors in the host's immune system. One of these markers is highly associated with a serious reaction to an HIV medication called abacavir, and its presence or absence is reflected in HIV's genes. Following these changes in HIV's genes give us an additional way to predict who will have serious side-effects from abacavir.
(2) We will be able to monitor how HIV evolves over time in response to this immune pressure, and how this changes with HIV treatment. The extent this evolution will give us insight into how the immune system works.
(3) We also propose to use a new, highly sensitive DNA sequencing method that has just been developed to follow these genetic changes in HIV, even when they are emerging at low levels within a patient's viral population.
Competitiondate
200910
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Swenson, Luke C
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $105,000~ $0~
