Grant: Operating Grant
Ottawa Hospital Research Institute
$509,626.00
Regulation of Inflammatory Response and Cholesterol efflux by ABCA1
FY 2012-13
Summary
ABCA1 has tow major functions: one is to promote cholesterol removal and thus make HDL (good cholesterol), another one
is to control inflammation. We propose that both these functions is originated from cell surface where ABCA1 is making the
cell wall more flexible. This makes cholesterol removal easier and also helps cells to fight inflammation.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
279591
Name
Zha Xiaohui
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Diabetes, Obesity, Lipid & Lipoprotein Disorders
Projecttitle
Regulation of Inflammatory Response and Cholesterol efflux by ABCA1
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$509,626
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Abca1; Atherosclerosis; Cholesterol; Cytokine; Gene Regulation; Inflammation; Lipid Raft; Macrophage
Abstract
ABCA1 has tow major functions: one is to promote cholesterol removal and thus make HDL (good cholesterol), another one
is to control inflammation. We propose that both these functions is originated from cell surface where ABCA1 is making the
cell wall more flexible. This makes cholesterol removal easier and also helps cells to fight inflammation.
Competitiondate
201303
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Zha, Xiaohui
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $509,626~ $0~
