Grant: CIHR-ICR / Cancer Research Society Partnership - Res. Gr. Cancer Prev.
Ottawa Hospital Research Institute
$69,834.00
Precision cancer prevention after venous thromboembolism by early detection of clonal hematopoiesis
FY 2025-26
Summary
Blood clots in the veins, known as venous thromboembolism (VTE), are often followed by a cancer diagnosis. About 1 in 20 people with VTE will be diagnosed with cancer within one year. While most research focuses on detecting cancer after VTE, little attention has been paid to cancer prevention in this high-risk group. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, inflammation-related condition caused by acquired genetic changes in blood cells. CHIP increases the risk of cancer and blood clots, yet it has rarely been studied together. Using large Canadian and international datasets, this study will examine whether CHIP and specific CHIP-related mutations increase cancer risk after VTE. The results will inform personalized cancer prevention strategies for people with VTE.
Department
Program
CIHR-ICR / Cancer Research Society Partnership - Res. Gr. Cancer Prev.
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
579832
Name
Xu Yan
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Cancer Research Society Inc.; Cancer Research Society Inc.
Instname2
Cancer Research
Prcname2
Special Cases
Projecttitle
Precision cancer prevention after venous thromboembolism by early detection of clonal hematopoiesis
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$69,834
Cihrequipment2
$0
Programname2
CIHR-ICR / Cancer Research Society Partnership - Res. Gr. Cancer Prev.
Keyworddelim
Early Detection And Screening; Targets And Biomarkers
Abstract
Blood clots in the veins, known as venous thromboembolism (VTE), are often followed by a cancer diagnosis. About 1 in 20 people with VTE will be diagnosed with cancer within one year. While most research focuses on detecting cancer after VTE, little attention has been paid to cancer prevention in this high-risk group. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, inflammation-related condition caused by acquired genetic changes in blood cells. CHIP increases the risk of cancer and blood clots, yet it has rarely been studied together. Using large Canadian and international datasets, this study will examine whether CHIP and specific CHIP-related mutations increase cancer risk after VTE. The results will inform personalized cancer prevention strategies for people with VTE.
Competitiondate
202602
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Xu, Yan
Approvedterm
2 ans 0 mois
Cihrcontribution2
~ $69,834~ $0~
