Grant: Team Grant: China-Canada: Alzheimer's Disease and Related Disorders
University of British Columbia
$1,000,000.00
From Down Syndrome to Alzheimer's Disease: the molecular mechanism underlying the dementia pathogenesis and the therapeutic potentials
FY 2011-12
Summary
Alzheimer's Disease (AD) is the most common neurodegenerative disorder leading to dementia. AD affects about 10% of the population over the age of 65. Down syndrome (DS) is the most common genetic cause of mental retardation, affecting approximately one in 700 to 1,000 babies. The majority of DS cases are caused by an extra copy of chromosome 21, thus also known as Trisomy 21 syndrome. Individuals with DS inevitably develop characteristic AD neuropathology including neuritic plaques and neurofibrillary tangles after middle age. The underlying mechanism leading to AD pathogenesis is not well defined and there is no effective disease-modified treatment for AD. DS is a valuable human model system for studying AD pathogenesis. Our working hypothesis is that alteration of the gene expression and protein functions plays an important role in AD pathogenesis in DS. This proposal seeks to use unique DS mouse and human model platforms to elucidate the molecular mechanism underlying AD pathogenesis in DS and identify novel biomarkers and drug targets for AD.
Department
Program
Team Grant: China-Canada: Alzheimer's Disease and Related Disorders
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
234241
Name
Song Weihong
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
National Natural Science Foundation of China (Haidian, Beijing)
Instname2
Aging
Theme2
Biomedical
Prcname2
Team Grant: China-Canada: Alzheimer's Disease and Related Disorders - Internal Review
Projecttitle
From Down Syndrome to Alzheimer's Disease: the molecular mechanism underlying the dementia pathogenesis and the therapeutic potentials
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$1,000,000
Cihrequipment2
$0
Programname2
Team Grant: China-Canada: Alzheimer's Disease and Related Disorders
Keyworddelim
Alzheimer'S Disease; Amyloid; Bace1; Down Syndrome; Ltp And Ltd; Molecular Genetics; Transgenic And Knockout; Two-Photon Imaging
Abstract
Alzheimer's Disease (AD) is the most common neurodegenerative disorder leading to dementia. AD affects about 10% of the population over the age of 65. Down syndrome (DS) is the most common genetic cause of mental retardation, affecting approximately one in 700 to 1,000 babies. The majority of DS cases are caused by an extra copy of chromosome 21, thus also known as Trisomy 21 syndrome. Individuals with DS inevitably develop characteristic AD neuropathology including neuritic plaques and neurofibrillary tangles after middle age. The underlying mechanism leading to AD pathogenesis is not well defined and there is no effective disease-modified treatment for AD. DS is a valuable human model system for studying AD pathogenesis. Our working hypothesis is that alteration of the gene expression and protein functions plays an important role in AD pathogenesis in DS. This proposal seeks to use unique DS mouse and human model platforms to elucidate the molecular mechanism underlying AD pathogenesis in DS and identify novel biomarkers and drug targets for AD.
Competitiondate
201105
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Song, Weihong; Li, Ting-Yu
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $1,000,000~ $0~
