Grant: Operating Grant
University of Ottawa
$813,750.00
Post-transcriptional Regulation of Utrophin in Skeletal Muscle: Implications for New Therapeutic Strategies for Duchenne Muscular Dystrophy
FY 2011-12
Summary
One possible approach to counteract the effects of Duchenne muscular dystrophy (DMD) consists in up-regulating the levels of a protein normally expressed in dystrophic muscle which could then functionally compensate for the lack of dystrophin. An ideal candidate for such a role is utrophin. Therefore, it becomes essential to understand the mechanisms regulating expression of utrophin in skeletal muscle to identify cellular targets that could ultimately be manipulated pharmacologically in order to increase expression of utrophin in muscle of DMD patients.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
253150
Name
Jasmin Bernard J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Cell Physiology
Projecttitle
Post-transcriptional Regulation of Utrophin in Skeletal Muscle: Implications for New Therapeutic Strategies for Duchenne Muscular Dystrophy
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$813,750
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Duchenne Muscular Dystrophy; Dystrophin; Mrna Stability; Post-Transcriptional Regulation; Skeletal Muscle; Therapy; Translation; Utrophin
Abstract
One possible approach to counteract the effects of Duchenne muscular dystrophy (DMD) consists in up-regulating the levels of a protein normally expressed in dystrophic muscle which could then functionally compensate for the lack of dystrophin. An ideal candidate for such a role is utrophin. Therefore, it becomes essential to understand the mechanisms regulating expression of utrophin in skeletal muscle to identify cellular targets that could ultimately be manipulated pharmacologically in order to increase expression of utrophin in muscle of DMD patients.
Competitiondate
201203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Jasmin, Bernard J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $813,750~ $0~
