Grant: Master's Award: Canada Graduate Scholarships
Institut de recherches cliniques de Montréal
$17,500.00
The role of apoB100-lipoproteins in fatty acid trapping in obese subjects; in vivo and in vitro models
FY 2009-10
Summary
Low efficiency of dietary fat storage in fat tissue may increase the risk of type 2 diabetes. We believe that atherogenic particles that carry cholesterol in the blood (commonly known as bad cholesterol or LDL) may decrease fat storage in fat tissue in human and therefore increase the risk of type 2 diabetes. The objective of this study is to examine the relation of the number of LDL to the regulation of fat metabolism in obese subjects. To examine this, we will compare the rate of storage of a high fat meal after 6 hours in 16 obese subjects with high numbers of LDL compared to 16 subjects with normal numbers of LDL (50% men: 50% women). Fat storage in these subjects will be measured in the whole body as well as in fat tissue biopsies. We hope that this project may explain why some obese subjects are more prone to develop type 2 diabetes.
Department
Program
Master's Award: Canada Graduate Scholarships
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
201302
Name
Salem Huda
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
Canada Graduate Scholarships Master's Awards A
Projecttitle
The role of apoB100-lipoproteins in fatty acid trapping in obese subjects; in vivo and in vitro models
Programtype2
Studentship Programs
Orgnameinp2
Institut de recherches cliniques de Montréal
Cihramount2
$17,500
Cihrequipment2
$0
Programname2
Master's Award: Canada Graduate Scholarships
Keyworddelim
Adipose Tisue Biopsies; Clinical And Basic Research; Ex Vivo And In Vitro Models; In Vivo; Isotope Ration Mass Spectrometry; Lipoprotein Metabolism; Metabolism; Nutrition; Obesity; Stable And Radioactive Isotopes; Type 2 Diabetes
Abstract
Low efficiency of dietary fat storage in fat tissue may increase the risk of type 2 diabetes. We believe that atherogenic particles that carry cholesterol in the blood (commonly known as bad cholesterol or LDL) may decrease fat storage in fat tissue in human and therefore increase the risk of type 2 diabetes. The objective of this study is to examine the relation of the number of LDL to the regulation of fat metabolism in obese subjects. To examine this, we will compare the rate of storage of a high fat meal after 6 hours in 16 obese subjects with high numbers of LDL compared to 16 subjects with normal numbers of LDL (50% men: 50% women). Fat storage in these subjects will be measured in the whole body as well as in fat tissue biopsies. We hope that this project may explain why some obese subjects are more prone to develop type 2 diabetes.
Competitiondate
201002
Approvedterm2
1 yr 0 mth
Pinamesdelim
Salem, Huda
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $17,500~ $0~
