Grant: Project Grant
University of Alberta
$975,375.00
A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system
FY 2022-23
Summary
Toxic proteins with abnormal shapes (misfolded) accumulate in the brain as we age and in many neurodegenerative disorders, including Huntington's disease, Parkinson's disease and Alzheimer's disease, inducing cellular stress. Healthy cells have many strategies to clear toxic proteins and prevent their aggregation and accumulation. However, with ageing and in neurodegenerative diseases, such mechanisms become less efficient and overwhelmed, contributing to brain cell death. In this proposal, we will investigate whether the formation of small fat droplets inside the cells may help trapping toxic misfolded proteins and facilitate their clearance, thus protecting cells and slowing down neurodegenerative diseases.
Department
Program
Project Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
468690
Name
Sipione Simonetta
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
A novel role for lipid droplets in proteostasis: Implications for misfolded protein diseases of the nervous system
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$975,375
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Heat Shock Response; Huntington'S Disease; Lipid Droplets; Misfolded Proteins; Neurodegeneration; Proteostasis Network
Abstract
Toxic proteins with abnormal shapes (misfolded) accumulate in the brain as we age and in many neurodegenerative disorders, including Huntington's disease, Parkinson's disease and Alzheimer's disease, inducing cellular stress. Healthy cells have many strategies to clear toxic proteins and prevent their aggregation and accumulation. However, with ageing and in neurodegenerative diseases, such mechanisms become less efficient and overwhelmed, contributing to brain cell death. In this proposal, we will investigate whether the formation of small fat droplets inside the cells may help trapping toxic misfolded proteins and facilitate their clearance, thus protecting cells and slowing down neurodegenerative diseases.
Competitiondate
202209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sipione, Simonetta
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $975,375~ $0~
