Grant: Project Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$1,028,925.00
The molecular basis of persistent HIV-specific CD4 T cell dysfunction
FY 2019-20
Summary
Antiviral therapy (ART) that blocks replication of HIV has resulted in a remarkable improvement in the quality of life for people living with HIV/AIDS. However, specific white cells that recognize HIV, called T cells, remain incapable of effectively fighting the virus on their own, and HIV quickly multiplies again if treatment is interrupted. In these studies, we propose to identify the mechanisms that prevent proper T cell responses against HIV in infected persons, and to look for ways to rescue the ability of these T cells to control HIV. We will seek to understand the "set of instructions" that determine the function of a subset of these T cells, called CD4 T cells, as they play an important role in controlling viral infections. The knowledge gained may help development of new treatments that will complement ART, inform HIV vaccine and cure strategies, and decrease the risk of clinical complications.
Department
Program
Project Grant
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
408708
Name
Kaufmann Daniel E
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
The molecular basis of persistent HIV-specific CD4 T cell dysfunction
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$1,028,925
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Antiretroviral Therapy (Art); Antiviral Immunity; Cd4 T Cell; Gene Expression; Hiv; Immune Exhaustion; Immune Reconstitution; Systems Biology (-Omics Technologies); T Cell Programming; Thelper Differentiation And Function
Abstract
Antiviral therapy (ART) that blocks replication of HIV has resulted in a remarkable improvement in the quality of life for people living with HIV/AIDS. However, specific white cells that recognize HIV, called T cells, remain incapable of effectively fighting the virus on their own, and HIV quickly multiplies again if treatment is interrupted. In these studies, we propose to identify the mechanisms that prevent proper T cell responses against HIV in infected persons, and to look for ways to rescue the ability of these T cells to control HIV. We will seek to understand the "set of instructions" that determine the function of a subset of these T cells, called CD4 T cells, as they play an important role in controlling viral infections. The knowledge gained may help development of new treatments that will complement ART, inform HIV vaccine and cure strategies, and decrease the risk of clinical complications.
Competitiondate
201909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Kaufmann, Daniel E
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,028,925~ $0~
