Grant: Operating Grant
University of Manitoba
$881,609.00
An assessment of psychological factors, inflammatory biomarkers and kidney complications; the Improving renal Complications in Adolescents with type 2 diabetes through REsearch (iCARE) cohort study
FY 2014-15
Summary
Youth with type 2 diabetes (T2D) have very high rates of kidney complications, as well as progression to end stage kidney disease. Traditional risk factors do not explain the disease burden in these high risk youth. We aim to evaluate the role of biological, psychological and social factors (BPS) and inflammation in the development of early kidney disease in youth with T2D. To accomplish this objective we will create a national cohort of youth with T2D to address the following aims: Aim 1. Characterize the primary BPS risk factors associated with early kidney injury in youth with T2D. Aim 2: Determine individual, family and community level factors that influence biological and psychological risk factors and behaviors (adherence) that could be modified to protect against early kidney injury. Aim 3: Determine if inflammation is the common pathway through which BPS risk factors lead to kidney injury in youth with T2D. This study will clarify the role of psychological factors in complications in youth with T2D, as well as identify new biomarkers for progression. Results will guide clinical care, as well as inform future intervention trials to be performed within the infrastructure developed through this national cohort.
Department
Program
Operating Grant
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
323683
Name
Dart Allison B
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
Clinical Investigation - A: Reproduction, Maternal, Child and Youth Health 2
Projecttitle
An assessment of psychological factors, inflammatory biomarkers and kidney complications; the Improving renal Complications in Adolescents with type 2 diabetes through REsearch (iCARE) cohort study
Programtype2
Operating Grants
Orgnameinp2
University of Manitoba
Cihramount2
$881,609
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Albuminuria; Biomarkers; Cohort; Inflammation; Psychological Factors; Type 2 Diabetes Mellitus; Youth
Abstract
Youth with type 2 diabetes (T2D) have very high rates of kidney complications, as well as progression to end stage kidney disease. Traditional risk factors do not explain the disease burden in these high risk youth. We aim to evaluate the role of biological, psychological and social factors (BPS) and inflammation in the development of early kidney disease in youth with T2D. To accomplish this objective we will create a national cohort of youth with T2D to address the following aims: Aim 1. Characterize the primary BPS risk factors associated with early kidney injury in youth with T2D. Aim 2: Determine individual, family and community level factors that influence biological and psychological risk factors and behaviors (adherence) that could be modified to protect against early kidney injury. Aim 3: Determine if inflammation is the common pathway through which BPS risk factors lead to kidney injury in youth with T2D. This study will clarify the role of psychological factors in complications in youth with T2D, as well as identify new biomarkers for progression. Results will guide clinical care, as well as inform future intervention trials to be performed within the infrastructure developed through this national cohort.
Competitiondate
201503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Dart, Allison B; Wicklow, Brandy A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $881,609~ $0~
