Grant: Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
University of Alberta
$105,000.00
Activation of SREBP2 activity in the absence of calreticulin
FY 2014-15
Summary
The Endoplasmic Reticulum, or ER, is a central organelle within the cell and is a hub for a variety of cellular functions. In particular, the ER is a site for the processing, quality control and secretion of newly synthesized proteins, all of which is in part, under the control of calreticulin, an ER protein chaperone. Cells deficient in calreticulin have a constitutively active sterol regulatory element binding protein, or SREBP, a transcription factor that is responsible for turning on genes involved in lipid metabolism. For the first time, we are investigating the role of calreticulin and disrupted ER homeostasis in energy metabolism, which will provide new insights into treatment for metabolic disorders.
Department
Program
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
327922
Name
Wang Wen-An
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Doctoral Research Awards - A
Projecttitle
Activation of SREBP2 activity in the absence of calreticulin
Programtype2
Studentship Programs
Orgnameinp2
University of Alberta
Cihramount2
$105,000
Cihrequipment2
$0
Programname2
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Keyworddelim
Calcium; Calreticulin; Endoplasmic Reticulum; Lipid Metabolism; Protein Folding; Sterol Regulatory Element Binding Protein
Abstract
The Endoplasmic Reticulum, or ER, is a central organelle within the cell and is a hub for a variety of cellular functions. In particular, the ER is a site for the processing, quality control and secretion of newly synthesized proteins, all of which is in part, under the control of calreticulin, an ER protein chaperone. Cells deficient in calreticulin have a constitutively active sterol regulatory element binding protein, or SREBP, a transcription factor that is responsible for turning on genes involved in lipid metabolism. For the first time, we are investigating the role of calreticulin and disrupted ER homeostasis in energy metabolism, which will provide new insights into treatment for metabolic disorders.
Competitiondate
201410
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Wang, Wen-An
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $105,000~ $0~
