Grant: Collaborative Health Research Projects
Ryerson University
$177,386.00
Patient-specific cartilage implants: development and surgical implantation
FY 2013-14
Summary
Damage to articular cartilage by arthritis or injury causes significant morbidity as the tissue has little potential for repair. One approach to resurface the damaged area with engineered cartilage. However, as only a limited number of cells can be extracted from a patient, the approach is restricted to the repair of small, localized defects. To extend potential treatment to a larger, more clinically relevant patient population, large-size constructs need to be developed. However, the confounding problem with large-sized implants is that the patient's anatomy at the lesion site needs to be taken into account as inadequate graft matching and imperfect restoration of the joint surface can lead to premature implant failure. The objective of this proposed study is to develop patient-specific engineered cartilage implants suitable for the repair of large, clinically-sized defects. Recently, we have developed an approach to create large-sized cartilage constructs (> 3 sq. cm) from a small population of cells (< 20,000) without a separate cell expansion phase or scaffold. The cells are cultivated in a bioreactor which elicits the extensive growth of cartilaginous tissue that can be matched to the shape, curvature and thickness of the defect site. To deliver the patient-specific implants at the desired location and orientation, we will use our computer-assisted surgical strategies developed for cartilage repair. This project translates the results from our previous work to develop and surgically implant, patient-specific engineered cartilage constructs to offer the prospect of treating large defects associated with osteoarthritis (OA) or trauma that cannot be addressed with currently available techniques. Ultimately, with these new technologies, patients will benefit from better clinical outcomes through proper implant matching resulting in a lower risk of implant failure. We expect that our methods will repair degenerative changes due to OA, and potentially delay or eliminate the need for joint replacement surgery
Program
Collaborative Health Research Projects
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
413680-2012
Name nom
Waldman, Stephen
Department département
Chemical Engineering
Organization id
43
Institution établissement
Ryerson University
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2013
Competition year année de concours
2012
Award amount
177386
Program id
CHRPJ
Program name en
Collaborative Health Research Projects
Program name fr
Projets de recherche concertée sur la santé
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
360
Committee name en
Collaborative Health Research Projects Selection Panel
Committee name fr
Comité de sélection de projets de recherche concertée sur la santé
Area of application code
1102
Area of application group en
Health, education and social services
Area of application group fr
Santé publique, éducation et services sociaux
Area of application en
Biomedical engineering
Area of application fr
Génie biomédical
Research subject code
1901
Research subject group en
Biomedical engineering
Research subject group fr
Génie biomédical
Research subject en
Biomedical technology
Research subject fr
Technologie biomédicale
Partie
2 & 3
Nb partie
3
Application title
Patient-specific cartilage implants: development and surgical implantation
Keyword
NSERC
Application summary
Damage to articular cartilage by arthritis or injury causes significant morbidity as the tissue has little potential for repair. One approach to resurface the damaged area with engineered cartilage. However, as only a limited number of cells can be extracted from a patient, the approach is restricted to the repair of small, localized defects. To extend potential treatment to a larger, more clinically relevant patient population, large-size constructs need to be developed. However, the confounding problem with large-sized implants is that the patient's anatomy at the lesion site needs to be taken into account as inadequate graft matching and imperfect restoration of the joint surface can lead to premature implant failure. The objective of this proposed study is to develop patient-specific engineered cartilage implants suitable for the repair of large, clinically-sized defects. Recently, we have developed an approach to create large-sized cartilage constructs (> 3 sq. cm) from a small population of cells (< 20,000) without a separate cell expansion phase or scaffold. The cells are cultivated in a bioreactor which elicits the extensive growth of cartilaginous tissue that can be matched to the shape, curvature and thickness of the defect site. To deliver the patient-specific implants at the desired location and orientation, we will use our computer-assisted surgical strategies developed for cartilage repair. This project translates the results from our previous work to develop and surgically implant, patient-specific engineered cartilage constructs to offer the prospect of treating large defects associated with osteoarthritis (OA) or trauma that cannot be addressed with currently available techniques. Ultimately, with these new technologies, patients will benefit from better clinical outcomes through proper implant matching resulting in a lower risk of implant failure. We expect that our methods will repair degenerative changes due to OA, and potentially delay or eliminate the need for joint replacement surgery
