Grant: Operating Grant

Homologous recombination is the process by which genetic information is exchanged between DNA molecules. It is of fundamental importance in living organisms. During the generation of eggs and sperm, homologous recombination between chromosomes generates genetic diversity. In the dividing cells of the body, homologous recombination is important in repairing breaks that occur in chromosomes. When homologous recombination doesn't work correctly, broken chromosomes can trigger cell death or chromosome rearrangements and mutations that are linked to cancer. Much of our knowledge of how homologous recombination works, comes from studies conducted in model organisms, such as yeast and bacteria. Unfortunately, we know less about this process as it occurs in mammalian cells. The research work of my laboratory is focused on understanding how homologous recombination aids in the repair of DNA breaks in mammalian cells and of the mechanisms involved. Our research contributes to an understanding of how cells maintain the stability of the DNA in their chromosomes. Eventually, there is the hope that this research will help in the design of therapeutic drugs and processes that can aid in cancer prevention.