Grant: Research Tools and Instruments - Category 1 (<$150,000)
Dalhousie University
$79,885.00
Spectrofluorometer for protein structure and function analysis
FY 2007-08
Summary
Proteins are the most functionally diverse biomolecules, and our collective research is trying to understand how they work. The proteins we study include a key protein involved in bacterial growth and pathogenesis, enzymes that are essential for cellular metabolism, membrane receptors, and collagen, the most abundant animal protein in the world. Our work will lead not only to greater knowledge of important biological processes, but also to development of new products and therapies for many diseases such as cancer and infection.As proteins are much too small to be seen, our research relies on special probes to report what is going on at the atomic to molecular level. One of the most useful tools for protein research is fluorescence, which can provide accurate and sensitive information about molecular environment, interactions, and dynamic events. The requested spectrofluorometer will allow us to investigate these properties for proteins with natural or attached fluorescent probes, using state-of-the-art accessories that can provide information about the dynamic events involved in protein structural changes and interactions.
Program
Research Tools and Instruments - Category 1 (<$150,000)
Recipient
Location
Nova Scotia, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
359447-2008
Name nom
Byers, David
Department département
Biochemistry and Molecular Biology
Organization id
79
Institution établissement
Dalhousie University
Province en
Nova Scotia
Province fr
Nouvelle-Écosse
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2007
Competition year année de concours
2008
Award amount
79885
Program id
EQPEQ
Program name en
Research Tools and Instruments - Category 1 (<$150,000)
Program name fr
Outils et instruments de recherche - catégorie 1 (<150 000$)
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
32
Committee name en
Cell Biology
Committee name fr
Biologie cellulaire
Area of application code
1201
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Life sciences (including biotechnology)
Area of application fr
Sciences de la vie (y compris biotechnologie)
Research subject code
5403
Research subject group en
Biochemistry
Research subject group fr
Biochimie
Research subject en
Proteins and peptides, amino acids
Research subject fr
Protéines et peptides, acides aminés
Partie
1
Nb partie
1
Application title
Spectrofluorometer for protein structure and function analysis
Keyword
NA
Application summary
Proteins are the most functionally diverse biomolecules, and our collective research is trying to understand how they work. The proteins we study include a key protein involved in bacterial growth and pathogenesis, enzymes that are essential for cellular metabolism, membrane receptors, and collagen, the most abundant animal protein in the world. Our work will lead not only to greater knowledge of important biological processes, but also to development of new products and therapies for many diseases such as cancer and infection.As proteins are much too small to be seen, our research relies on special probes to report what is going on at the atomic to molecular level. One of the most useful tools for protein research is fluorescence, which can provide accurate and sensitive information about molecular environment, interactions, and dynamic events. The requested spectrofluorometer will allow us to investigate these properties for proteins with natural or attached fluorescent probes, using state-of-the-art accessories that can provide information about the dynamic events involved in protein structural changes and interactions.
