Grant: Project Grant
University of Guelph
$745,876.00
Alpha-Synuclein oligomerization in the pathogenesis of Parkinson's Disease
FY 2017-18
Summary
While Parkinson's Disease (PD) is the most common neurodegenerative movement disorder, the disease is in fact, highly complex, and many patients suffer from both motor and non-motor symptoms. Cell death in PD is associated with accumulation protein aggregates that consist primarily of the protein synuclein in cells of the brain. We have identified a means of dissolving synuclein aggregates in brain cells. Using Parkinson patient-derived stem cells coupled with animal models of the disease, this proposal will explore whether dissolving synuclein aggregates protects from cellular dysfunction in PD.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
382519
Name
Ryan Scott D
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Alpha-Synuclein oligomerization in the pathogenesis of Parkinson's Disease
Programtype2
Operating Grants
Orgnameinp2
University of Guelph
Cihramount2
$745,876
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cytoskeleton; Electrophysiology; Human Pluripotent Stem Cells; Microtubule; Neurodegeneration; Synapse; Synucleinopathy; Tauopathy; Transgenic Animals
Abstract
While Parkinson's Disease (PD) is the most common neurodegenerative movement disorder, the disease is in fact, highly complex, and many patients suffer from both motor and non-motor symptoms. Cell death in PD is associated with accumulation protein aggregates that consist primarily of the protein synuclein in cells of the brain. We have identified a means of dissolving synuclein aggregates in brain cells. Using Parkinson patient-derived stem cells coupled with animal models of the disease, this proposal will explore whether dissolving synuclein aggregates protects from cellular dysfunction in PD.
Competitiondate
201803
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Ryan, Scott D
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $745,876~ $0~
