Grant: International COEN Initiative in Neurodegeneration
University of Ottawa
$240,724.00
Mechanisms of amyloid-beta clearance in models of vascular cognitive impairment and mixed dementia
FY 2012-13
Summary
In the aging brain two major events contribute to loss of memory and dementia: disease of brain vessels and accumulation of a protein, amyloid, that causes brain inflammation. This project will study how these processes work together to cause cognitive decline. The project will also test effects of new molecules designed to speed up the elimination of toxic amyloid from the brain. This will be evaluated in animal models using strong expertise of German and Canadian researchers and their advanced imaging techniques. Should the treatments prove effective, the project will proceed to more rigorous evaluation of these molecules for their application in human patients.
Department
Program
International COEN Initiative in Neurodegeneration
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
283731
Name
Stanimirovic Danica
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Deutsche Zentrum für Neurodegenerative Erkrankungen (Germany)
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Special Cases
Projecttitle
Mechanisms of amyloid-beta clearance in models of vascular cognitive impairment and mixed dementia
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$240,724
Cihrequipment2
$0
Programname2
International COEN Initiative in Neurodegeneration
Keyworddelim
Amyloid Beta; Blood-Brain Barrier; Imaging; Inflammation; Transporters; Vascular Dementia
Abstract
In the aging brain two major events contribute to loss of memory and dementia: disease of brain vessels and accumulation of a protein, amyloid, that causes brain inflammation. This project will study how these processes work together to cause cognitive decline. The project will also test effects of new molecules designed to speed up the elimination of toxic amyloid from the brain. This will be evaluated in animal models using strong expertise of German and Canadian researchers and their advanced imaging techniques. Should the treatments prove effective, the project will proceed to more rigorous evaluation of these molecules for their application in human patients.
Competitiondate
201303
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Stanimirovic, Danica
Approvedterm
2 ans 0 mois
Cihrcontribution2
Inst of Neurosc Mental Hlth &A~ $120,362~ $0~Institute of Aging~ $120,362~ $0~
