Grant: Operating Grant

Numerous hormones and drugs have effects which are beneficial to the optimal functioning of the cardiovascular system. However, when used in combination, or at less than optimal concentrations, these agents can have negative effects on cells of the cardiovascular system. While there are many sites at which drugs and hormones can interact to bring about these unwanted effects, one factor which is likely important involves our limited knowledge concerning the mechanisms by which hormones and drugs influence cell functioning. Our studies are aimed at testing the hypothesis that the actions of hormones, or drugs, in cells are regulated by a system that allows local cellular effects and that unwanted effects arise, at least in part, due to unwanted effects in other parts of the cells. It is our belief that by increasing our understanding of the mechanisms through which cells organize their signaling systems, that more selective drug effects can be ensured.