Grant: Canadian Microbiome Initiative - LOI
University of British Columbia
$0.00
Impact of the Microbiota on Immune Development and Disease
FY 2009-10
Summary
Recent data indicate that the intestinal microbiota impact significantly on the development of the immune system. Moreover, there is mounting evidence that the microbiota also affect disease, including allergic diseases such as asthma. This Team will use their extensive combined expertise to probe the role of the microbiota on immune development and disease, including asthma, in both the murine asthma model and the CHILD cohort study of 5000 Canadian children. Microbiota will be altered and characterized in mice by antibiotics, and the impact on immune development and disease determined. Complementing this will be microbiota and immune status studies from the CHILD cohort study. Results from both the murine and human studies will be used to translate this knowledge as appropriate towards altering disease outcomes.
Department
Program
Canadian Microbiome Initiative - LOI
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
196644
Name
Finlay Barton B
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Emerging Team Grant: Canadian Microbiome Initiative
Projecttitle
Impact of the Microbiota on Immune Development and Disease
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$0
Cihrequipment2
$0
Programname2
Canadian Microbiome Initiative - LOI
Keyworddelim
Allergic Diseases; Asthma; Immune Development; Intestinal Microbiota; Microbial Populations
Abstract
Recent data indicate that the intestinal microbiota impact significantly on the development of the immune system. Moreover, there is mounting evidence that the microbiota also affect disease, including allergic diseases such as asthma. This Team will use their extensive combined expertise to probe the role of the microbiota on immune development and disease, including asthma, in both the murine asthma model and the CHILD cohort study of 5000 Canadian children. Microbiota will be altered and characterized in mice by antibiotics, and the impact on immune development and disease determined. Complementing this will be microbiota and immune status studies from the CHILD cohort study. Results from both the murine and human studies will be used to translate this knowledge as appropriate towards altering disease outcomes.
Competitiondate
200911
Approvedterm2
0 yr 0 mth
Pinamesdelim
Finlay, Barton B; McNagny, Kelly M; Mohn, William W
Approvedterm
0 an 0 mois
