Grant: Operating Grant
University of Alberta
$813,784.00
A Functional Nuclear Pyruvate Dehydrogenase Complex is Important for a Mitochondria-Independent Generation of Acetyl-CoA and Histone Acetylation in the Nucleus
FY 2012-13
Summary
The regulation of genetic information in the cell depends on the function of the energy factories of the cell, the mitochondria. This way energy availability can be coordinated with the growth of the cell, which is regulated by the nucleus. However, there are conditions that the cells show increased growth but the mitochondria are inhibited, like cancer or low oxygen levels. In this work we propose to characterize a completely new mechanism by which the cell can regulate the genetic information independent of the mitochondria. We will use several sophisticated techniques to prove this new idea, which is supported by our early preliminary experiments. If we are correct, this new information will shed light in many unexplored areas of medicine and biology, where energy merges with genetic regulation and may result in the discovery of new therapies for devastating diseases like cancer, but also neurodegenerative diseases of heart failure.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
267111
Name
Michelakis Evangelos D
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
A Functional Nuclear Pyruvate Dehydrogenase Complex is Important for a Mitochondria-Independent Generation of Acetyl-CoA and Histone Acetylation in the Nucleus
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$813,784
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cancer; Cell Biology; Epigenetics; Molecular Biology
Abstract
The regulation of genetic information in the cell depends on the function of the energy factories of the cell, the mitochondria. This way energy availability can be coordinated with the growth of the cell, which is regulated by the nucleus. However, there are conditions that the cells show increased growth but the mitochondria are inhibited, like cancer or low oxygen levels. In this work we propose to characterize a completely new mechanism by which the cell can regulate the genetic information independent of the mitochondria. We will use several sophisticated techniques to prove this new idea, which is supported by our early preliminary experiments. If we are correct, this new information will shed light in many unexplored areas of medicine and biology, where energy merges with genetic regulation and may result in the discovery of new therapies for devastating diseases like cancer, but also neurodegenerative diseases of heart failure.
Competitiondate
201209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Michelakis, Evangelos D
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $813,784~ $0~
