Grant: Operating Grant
University of Guelph
$857,094.00
Structural Elucidation and Characterization of Bacterial Virulence Factors from Pathogenic Bacteria
FY 2009-10
Summary
We are using a technique called "Protein Crystallography" to elucidate the three-dimensional structures of bacterial toxins in complex with their host cell target proteins. We believe that this new knowledge of protein structure of these toxins will improve our understanding of their mechanisms of action. This enhanced knowledge will aid in the design and characterization of inhibitors against these bacterial factors that should translate into therapeutics for the treatment of bacterial diseases in man.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
201506
Name
Merrill Rod A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - A
Projecttitle
Structural Elucidation and Characterization of Bacterial Virulence Factors from Pathogenic Bacteria
Programtype2
Operating Grants
Orgnameinp2
University of Guelph
Cihramount2
$857,094
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Bacterial Infections And Diseases; Bacterial Virulence Factors; Bioinformatics; Enzyme Inhibitors; Enzyme Mechanisms; Fluorescence Spectroscopy; Protein Crystallography; Protein-Protein Interactions
Abstract
We are using a technique called "Protein Crystallography" to elucidate the three-dimensional structures of bacterial toxins in complex with their host cell target proteins. We believe that this new knowledge of protein structure of these toxins will improve our understanding of their mechanisms of action. This enhanced knowledge will aid in the design and characterization of inhibitors against these bacterial factors that should translate into therapeutics for the treatment of bacterial diseases in man.
Competitiondate
201003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Merrill, Rod A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $857,094~ $0~
