Grant: Operating Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$570,000.00
Mechanosensitive ATP release in the lungs
FY 2008-09
Summary
Adenosine 5'-triphosphate (ATP) functions as extracellular signaling molecule in most tissues. In the lungs, ATP is a potent stimulator of surfactant secretion and modulator of muciliary clearance but sources and mechanisms of its release remain unknown. We have previously discovered, that non-lytic mechanical stimuli, such as cell stretch, cell deformation, shear stress and hypotonic swelling, result in calcium-dependent ATP secretion from lung epithelial cells. Our goal is to identify and characterize the mechanisms of such ATP release. Understanding these mechanisms may help to design new therapeutic strategies for the treatment of several diseases, including chronic bronchitis, cystic fibrosis and asthma.
Department
Program
Operating Grant
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
179317
Name
Grygorczyk Ryszard
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Respiratory System
Projecttitle
Mechanosensitive ATP release in the lungs
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$570,000
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Adenosine Triphosphate Release; Airway Epithelia; Asthma; Cystic Fibrosis; Exocytosis; Tirf Microscopy
Abstract
Adenosine 5'-triphosphate (ATP) functions as extracellular signaling molecule in most tissues. In the lungs, ATP is a potent stimulator of surfactant secretion and modulator of muciliary clearance but sources and mechanisms of its release remain unknown. We have previously discovered, that non-lytic mechanical stimuli, such as cell stretch, cell deformation, shear stress and hypotonic swelling, result in calcium-dependent ATP secretion from lung epithelial cells. Our goal is to identify and characterize the mechanisms of such ATP release. Understanding these mechanisms may help to design new therapeutic strategies for the treatment of several diseases, including chronic bronchitis, cystic fibrosis and asthma.
Competitiondate
200903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Grygorczyk, Ryszard
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $570,000~ $0~
