Grant: CIHR Fellowship
York University (Toronto, Ontario)
$135,000.00
Analysis of the mechanisms and functional significance of adiponectin-stimulated autophagy in the heart.
FY 2020-21
Summary
Many reports have established a correlation between obesity and diabetes with cardiovascular complications such as heart failure. This occurs due to changes in the structure and function of the heart, yet the precise mechanisms responsible for regulating these changes in diabetes remain to be determined.
This project will focus on the role played by a substance (adiponectin) which is released from fat cells. Upon release, adiponectin can travel in the bloodstream to have effects in the heart. Interestingly, the amount of adiponectin circulating in the blood decreases in obese and diabetic individuals. We intend to determine how too much or too little adiponectin alters the structure and function of the heart.
Research has shown cardioprotective effects of adiponectin and this has generated tremendous interest in recent years about its therapeutic potential. Yet we still need to understand more details about how the effects mediated by adiponectin on the heart occur to facilitate development of new treatments.
Department
Program
CIHR Fellowship
Recipient
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
440955
Name
da Silva Rosa Simone C
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
Analysis of the mechanisms and functional significance of adiponectin-stimulated autophagy in the heart.
Programtype2
Fellowship Programs
Orgnameinp2
York University (Toronto, Ontario)
Cihramount2
$135,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Adiponectin; Autophagy; Cardiomyocyte; Diabetes; Heart Failure; Inflammation; Ischemia/Reperfusion; Knockout; Metabolism; Obesity
Abstract
Many reports have established a correlation between obesity and diabetes with cardiovascular complications such as heart failure. This occurs due to changes in the structure and function of the heart, yet the precise mechanisms responsible for regulating these changes in diabetes remain to be determined.
This project will focus on the role played by a substance (adiponectin) which is released from fat cells. Upon release, adiponectin can travel in the bloodstream to have effects in the heart. Interestingly, the amount of adiponectin circulating in the blood decreases in obese and diabetic individuals. We intend to determine how too much or too little adiponectin alters the structure and function of the heart.
Research has shown cardioprotective effects of adiponectin and this has generated tremendous interest in recent years about its therapeutic potential. Yet we still need to understand more details about how the effects mediated by adiponectin on the heart occur to facilitate development of new treatments.
Competitiondate
202012
Approvedterm2
3 yrs 0 mth
Pinamesdelim
da Silva Rosa, Simone C
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $135,000~ $0~
