Grant: CIHR - ICR / Cancer Research Society Partnership - Research Grants
Memorial University of Newfoundland
$62,500.00
A new handle on a known target: structure-based discovery of FPP synthase inhibitors targeting a cryptic pocket
FY 2022-23
Summary
Our goal isto find drug candidate molecules that can block an enzyme called farnesyl pyrophosphate synthase. Blocking this enzyme can reduce the cellular activitiesthat cause cancer, making it a promising strategy for treating cancer. We will use an approach known as structure-based drug design. By applying our in-depth knowledge of the enzyme’s 3D structure, we will find small moleculesthat can block the enzyme by sticking to a specific target site on the enzyme. The effectiveness of the identified molecules will be tested in different types of cancer cells. The strong blockers of farnesyl pyrophosphate synthase that we find through this study will provide a valuable new way of treating cancer.
Department
Program
CIHR - ICR / Cancer Research Society Partnership - Research Grants
Recipient
Location
Newfoundland and Labrador, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
488214
Name
Park Jaeok
Region
Newfoundland and Labrador
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Cancer Research Society Inc.; Cancer Research Society Inc.
Instname2
Cancer Research
Prcname2
Special Cases
Projecttitle
A new handle on a known target: structure-based discovery of FPP synthase inhibitors targeting a cryptic pocket
Programtype2
Operating Grants
Orgnameinp2
Memorial University of Newfoundland
Cihramount2
$62,500
Cihrequipment2
$0
Programname2
CIHR - ICR / Cancer Research Society Partnership - Research Grants
Keyworddelim
Chemotherapy And Radiotherapy
; Drug Repurposing; Targets And Biomarkers
Abstract
Our goal isto find drug candidate molecules that can block an enzyme called farnesyl pyrophosphate synthase. Blocking this enzyme can reduce the cellular activitiesthat cause cancer, making it a promising strategy for treating cancer. We will use an approach known as structure-based drug design. By applying our in-depth knowledge of the enzyme’s 3D structure, we will find small moleculesthat can block the enzyme by sticking to a specific target site on the enzyme. The effectiveness of the identified molecules will be tested in different types of cancer cells. The strong blockers of farnesyl pyrophosphate synthase that we find through this study will provide a valuable new way of treating cancer.
Competitiondate
202302
Approvedterm2
1 yr 0 mth
Pinamesdelim
Park, Jaeok
Approvedterm
1 an 0 mois
Cihrcontribution2
ICR~ $62,500~ $0~
