Grant: Doctoral Research Award - Priority Announcement: Patient-Oriented Research
University of Manitoba
$105,000.00
The effect of flaxseed and flax oil on blood pressure and vascular health in hypertensive patients in a randomized double blinded placebo controlled clinical trial.
FY 2011-12
Summary
Background:High blood pressure is a prevalent condition worldwide that is important to treat because it is a major risk factor for heart disease. In 2008, 13.4 million people died of heart disease, stroke, or other cerebrovascular diseases which accounted for one quarter of all deaths globally in 2008. Approximately 19% of Canadians aged 20-79 years are living with hypertension (20% with pre-hypertension) & the prevalence increases with age to 53.2% in those aged 60-79. Additionally, in 1998, 13.2 million visits were made to physicians in Canada for hypertension management.
Functional foods have been attributed with health promoting characteristics that can improve disease states & quality of life. My study will be investigating the functional food flaxseed & natural health product flax oil. Flaxseed is a Canadian grown crop that has many nutritional components: omega 3 fatty acid alpha-linolenic acid, lignans, protein, antioxidants, & fibre. These components may all contribute to heart health & lower blood pressure. Flax oil will also be investigated (containing alpha-linolenic acid) to understand if the beneficial components are the fatty acids or a synergistic effect of all the components of flaxseed.
Hypothesis:The patient group administered flaxseed will experience the greatest decrease in blood pressure & the greatest improvement in vascular health.
Experimental Details:The proposed project will investigate the effects of flaxseed & flax oil on blood pressure, vascular health, exercise performance, cardiac functioning, & incidence of stroke/heart attack in patients will newly diagnosed high blood pressure. The clinical trial will be randomized, double blinded, & placebo controlled.
Significance:This study will elucidate the potential cardiovascular benefits of flaxseed & flax oil. Our hope it to find a way to help reduce the prevalence of heart disease, promote health & the quality of life of Canadians while reducing the burden on our healthcare system.
Department
Program
Doctoral Research Award - Priority Announcement: Patient-Oriented Research
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
245977
Name
Caligiuri Stephanie P
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
Doctoral Research Awards - A
Projecttitle
The effect of flaxseed and flax oil on blood pressure and vascular health in hypertensive patients in a randomized double blinded placebo controlled clinical trial.
Programtype2
Studentship Programs
Orgnameinp2
University of Manitoba
Cihramount2
$105,000
Cihrequipment2
$0
Programname2
Doctoral Research Award - Priority Announcement: Patient-Oriented Research
Keyworddelim
Cardiac Functioning; Cardiology; Flaxseed; Hypertension; Nutrition; Vascular Health
Abstract
Background:High blood pressure is a prevalent condition worldwide that is important to treat because it is a major risk factor for heart disease. In 2008, 13.4 million people died of heart disease, stroke, or other cerebrovascular diseases which accounted for one quarter of all deaths globally in 2008. Approximately 19% of Canadians aged 20-79 years are living with hypertension (20% with pre-hypertension) & the prevalence increases with age to 53.2% in those aged 60-79. Additionally, in 1998, 13.2 million visits were made to physicians in Canada for hypertension management.
Functional foods have been attributed with health promoting characteristics that can improve disease states & quality of life. My study will be investigating the functional food flaxseed & natural health product flax oil. Flaxseed is a Canadian grown crop that has many nutritional components: omega 3 fatty acid alpha-linolenic acid, lignans, protein, antioxidants, & fibre. These components may all contribute to heart health & lower blood pressure. Flax oil will also be investigated (containing alpha-linolenic acid) to understand if the beneficial components are the fatty acids or a synergistic effect of all the components of flaxseed.
Hypothesis:The patient group administered flaxseed will experience the greatest decrease in blood pressure & the greatest improvement in vascular health.
Experimental Details:The proposed project will investigate the effects of flaxseed & flax oil on blood pressure, vascular health, exercise performance, cardiac functioning, & incidence of stroke/heart attack in patients will newly diagnosed high blood pressure. The clinical trial will be randomized, double blinded, & placebo controlled.
Significance:This study will elucidate the potential cardiovascular benefits of flaxseed & flax oil. Our hope it to find a way to help reduce the prevalence of heart disease, promote health & the quality of life of Canadians while reducing the burden on our healthcare system.
Competitiondate
201110
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Caligiuri, Stephanie P
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $105,000~ $0~
