Grant: Fellowship - PA: Great West Life/CIHR - Depression Research and Intervention
Centre for Addiction and Mental Health (Toronto)
$55,000.00
Effects of deep brain stimulation (DBS) on reward deficits in a rodent model of anhedonia in depression.
FY 2011-12
Summary
Deep brain stimulation (DBS) has shown promising results in treatment-resistant depression. DBS involves the electrical stimulation of brain sites through chronically implanted electrodes. The mechanism of the effectiveness of DBS remains unknown. This proposed study will examine the effects of DBS in a rodent model of anhedonia - the diminished ability to experience pleasure - a core symptom of depression. Rats trained to give themselves electrical stimulation to their brain's pleasure/reward areas will be challenged with chemical, environmental and social stressors to induce anhedonia. They will then be treated with DBS and the effectiveness of DBS to relieve the anhedonia symptoms will be assessed. This study will determine if DBS is effective in this model of anhedonia and provide a basis for more intensive studies of the mechanisms of DBS.
Department
Program
Fellowship - PA: Great West Life/CIHR - Depression Research and Intervention
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
243013
Name
Scott Brian W
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
The Great-West Life Assurance Company (Winnipeg, Manitoba); University of Ottawa Institute of Mental Health Research
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
Effects of deep brain stimulation (DBS) on reward deficits in a rodent model of anhedonia in depression.
Programtype2
Fellowship Programs
Orgnameinp2
Centre for Addiction and Mental Health (Toronto)
Cihramount2
$55,000
Cihrequipment2
$0
Programname2
Fellowship - PA: Great West Life/CIHR - Depression Research and Intervention
Keyworddelim
Anhedonia; Brain Stimulation Reward; Deep Brain Stimulation; Depression; Intracranial Self Stimulation; Mood Disorders; Pleasure; Reward; Stress
Abstract
Deep brain stimulation (DBS) has shown promising results in treatment-resistant depression. DBS involves the electrical stimulation of brain sites through chronically implanted electrodes. The mechanism of the effectiveness of DBS remains unknown. This proposed study will examine the effects of DBS in a rodent model of anhedonia - the diminished ability to experience pleasure - a core symptom of depression. Rats trained to give themselves electrical stimulation to their brain's pleasure/reward areas will be challenged with chemical, environmental and social stressors to induce anhedonia. They will then be treated with DBS and the effectiveness of DBS to relieve the anhedonia symptoms will be assessed. This study will determine if DBS is effective in this model of anhedonia and provide a basis for more intensive studies of the mechanisms of DBS.
Competitiondate
201110
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Scott, Brian W
Approvedterm
3 ans 0 mois
Cihrcontribution2
Inst of Neurosc Mental Hlth &A~ $55,000~ $0~
