Grant: Research Tools and Instruments - Category 1 (<$150,000)
Université du Québec à Montréal
$74,000.00
Supporting infrastructure required to install a caenorhabditis elegans functional genomic platform
FY 2007-08
Summary
The integration by cells of multiple intercellular signals is of prime importance for the development of multicellular organisms. However, these mechanisms are still poorly understood. We will use the microscopic worm, Caenorhabditis elegans as a model system to provide a better understanding of the composition and topology of regulatory machineries involved in cell signaling integration events during embryonic development. To do so, we will develop an integrative genomic approach consisting in the generation and integration of complementary layers of biological information. Some pieces of equipment are required to develop the proposed research program. These equipments are required as a complement of the infrastructure requested to the Canadian Foundation for Innovation for the installation of a C. elegans functional genomic platform within the UQAM science faculty. These equipments consist in: (i) an ultra-low temperature freezer; (ii) a thermocycler; (iii) a refrigerated bench-top centrifuge; (iv) a cold incubator-shaker; (v) a microparticle bombardment system. The requested equipments are essential for the development of different experimental steps of the proposed program. It is also required to complete the installation of a C. elegans genomic platform that will be appropriate to the development of a large number of projects and program in the future. These equipments will enable the generation of dynamic models of cell signaling integration machineries conserved throughout Eukaryotes and involved in a large number of human pathologies. The research supported by the proposed infrastructure will consequently bring a better understanding of cell signaling events. It will also provide the scientific community with dynamic models that could be used to better understand number of pathogenic processes. This infrastructure will also provide the students working in my laboratory with equipment required to support a research of quality and consequently ensure the success of their future career in academia or in the industry.
Program
Research Tools and Instruments - Category 1 (<$150,000)
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
344802-2007
Name nom
Jenna, Sarah
Department département
Chimie
Organization id
57
Institution établissement
Université du Québec à Montréal
Province en
Québec
Province fr
Québec
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2007
Competition year année de concours
2007
Award amount
74000
Program id
EQPEQ
Program name en
Research Tools and Instruments - Category 1 (<$150,000)
Program name fr
Outils et instruments de recherche - catégorie 1 (<150 000$)
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
33
Committee name en
Molec. & Develop. Genetics
Committee name fr
Gén. moléculaire et dévelop.
Area of application code
1201
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Life sciences (including biotechnology)
Area of application fr
Sciences de la vie (y compris biotechnologie)
Research subject code
5003
Research subject group en
Genetics
Research subject group fr
Génétique
Research subject en
Developmental genetics
Research subject fr
Génétique du développement
Partie
1
Nb partie
1
Application title
Supporting infrastructure required to install a caenorhabditis elegans functional genomic platform
Keyword
NA
Application summary
The integration by cells of multiple intercellular signals is of prime importance for the development of multicellular organisms. However, these mechanisms are still poorly understood. We will use the microscopic worm, Caenorhabditis elegans as a model system to provide a better understanding of the composition and topology of regulatory machineries involved in cell signaling integration events during embryonic development. To do so, we will develop an integrative genomic approach consisting in the generation and integration of complementary layers of biological information. Some pieces of equipment are required to develop the proposed research program. These equipments are required as a complement of the infrastructure requested to the Canadian Foundation for Innovation for the installation of a C. elegans functional genomic platform within the UQAM science faculty. These equipments consist in: (i) an ultra-low temperature freezer; (ii) a thermocycler; (iii) a refrigerated bench-top centrifuge; (iv) a cold incubator-shaker; (v) a microparticle bombardment system. The requested equipments are essential for the development of different experimental steps of the proposed program. It is also required to complete the installation of a C. elegans genomic platform that will be appropriate to the development of a large number of projects and program in the future. These equipments will enable the generation of dynamic models of cell signaling integration machineries conserved throughout Eukaryotes and involved in a large number of human pathologies. The research supported by the proposed infrastructure will consequently bring a better understanding of cell signaling events. It will also provide the scientific community with dynamic models that could be used to better understand number of pathogenic processes. This infrastructure will also provide the students working in my laboratory with equipment required to support a research of quality and consequently ensure the success of their future career in academia or in the industry.
