Grant: Operating Grant
University of British Columbia
$613,716.00
Epigenetic and Transcriptomic Disturbances in HIV-Associated COPD
FY 2014-15
Summary
People living with HIV often develop lung disease similar to long-time smokers. Unlike long-time smokers, they develop this lung disease earlier in their lives and appear to suffer more from this lung disease. We do not know why this occurs exactly, but clues from cells suggests that people with HIV age faster. This aging process can be seen in both the lung cells and the blood cells of HIV patients. In this proposal, we aim to investigate how we can use these aging signals in the lung and in the blood to predict which HIV patients have the highest risk of developing lung disease.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
322295
Name
Man S.F. Paul
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
Respiratory System
Projecttitle
Epigenetic and Transcriptomic Disturbances in HIV-Associated COPD
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$613,716
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Aging; Emphysema; Epigenetics; Hiv
Abstract
People living with HIV often develop lung disease similar to long-time smokers. Unlike long-time smokers, they develop this lung disease earlier in their lives and appear to suffer more from this lung disease. We do not know why this occurs exactly, but clues from cells suggests that people with HIV age faster. This aging process can be seen in both the lung cells and the blood cells of HIV patients. In this proposal, we aim to investigate how we can use these aging signals in the lung and in the blood to predict which HIV patients have the highest risk of developing lung disease.
Competitiondate
201503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Man, S.F. Paul
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $613,716~ $0~
