Grant: Discovery Grants Program - Individual

Since the advent of the germ theory of disease, understanding the mechanisms of pathogen propagation and survival has formed a major branch of the natural sciences. My research program focuses on the development of an immuno-epidemiological (IE) framework that is comprehensively informed by in-host and epidemiological models of infectious diseases, and the underlying biological and mathematical simplifying assumptions of these models. In this proposed research program our overriding objective is to quantify the range, distribution, and variability of key results (both qualitative and quantitative) from these models related to applications in the health and life sciences. The primary research outcome will be a mathematically tractable and biologically relevant IE modelling framework that is exhaustive in mathematical formulation and representation of biological processes (given all simplifying assumptions). New mathematical and computational tools will result from this work, including global stability analysis and bifurcation theory, moment closure and stochastic modelling, and sensitivity analysis. The research proposed lies in the NSE domain (mathematical models and tools), with relevance to health and related life sciences.