Grant: Operating Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$600,626.00
Use of TGFbi to improve the efficacy of islet transplantation and promote islet regeneration
FY 2011-12
Summary
Islet transplantation is an effective treatment for type I diabetes. However, islets when isolated from the pancreas for transplantation will lose the support from their usual surroundings and tend to die. TGFbi is a molecule that is normally found in the surroundings of islets. We showed that it is helpful to the health and growth of islets. We intend to use this molecule to promote the health and growth of the transplanted islets. We will also dissect TGFbi molecularly to see which part in this molecule is critical for its function on islets and which part is harmful, in order to create a most effective molecule. We will study how TGFbi exerts its effects on islets. The results of our study can be used in patients to improve the effectiveness of islet transplantation.
Department
Program
Operating Grant
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
251887
Name
Wu Jiangping
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Cell Biology & Mechanisms of Disease
Projecttitle
Use of TGFbi to improve the efficacy of islet transplantation and promote islet regeneration
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$600,626
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Gene Knockout Mice; Islet Survival; Islet Transplantation; Tgfbi; Transgenic Mice; Type I Diabetes
Abstract
Islet transplantation is an effective treatment for type I diabetes. However, islets when isolated from the pancreas for transplantation will lose the support from their usual surroundings and tend to die. TGFbi is a molecule that is normally found in the surroundings of islets. We showed that it is helpful to the health and growth of islets. We intend to use this molecule to promote the health and growth of the transplanted islets. We will also dissect TGFbi molecularly to see which part in this molecule is critical for its function on islets and which part is harmful, in order to create a most effective molecule. We will study how TGFbi exerts its effects on islets. The results of our study can be used in patients to improve the effectiveness of islet transplantation.
Competitiondate
201203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Wu, Jiangping
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $600,626~ $0~
