Grant: Team Grant: Mental Disorders
University of British Columbia
$155,250.00
Subthalamic Nucleus Deep Brain Stimulation for the treatment of Impulse Control Disorders
FY 2010-11
Summary
The lack of control of impulsivity (i.e. Impulse Control Disorders; ICD) can lead to various disorders that encompass drug addiction, pathological gambling, compulsive shopping, binge eating, hypersexuality. In the past years, the role of the subthalamic nucleus (STN) in impulsivity has been highlighted. The STN is the current target for the surgical treatment of Parkinson's Disease using Deep Brain Stimulation (DBS). Interestingly, PD is a disease often associated with ICD. The aim of the present project is thus to characterise the effects of STN DBS in various forms of ICD in intact rats and assessed in various behavioural tasks measuring impulsive choice, gambling and addiction. The studies carried out in rats will be paralleled by clinical studies characterizing the effects of STN DBS applied in PD patients on ICD, measured in various tasks such as Go/NoGo and the Iowa gambling task. This project, bringing together experts in rat STN, impulsivity and clinical experts of STN DBS in patients, should lead to a better understanding of STN contribution in ICD processes and may also lead to a more refined prescription of STN DBS for the treatment of ICD.
Department
Program
Team Grant: Mental Disorders
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
219633
Name
Winstanley Catharine A
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Ministry of Science and Innovation (Spain); The French National Research Agency (France)
Prcname2
Special Cases
Projecttitle
Subthalamic Nucleus Deep Brain Stimulation for the treatment of Impulse Control Disorders
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$155,250
Cihrequipment2
$24,227
Programname2
Team Grant: Mental Disorders
Keyworddelim
Impulse Control Disorders
Abstract
The lack of control of impulsivity (i.e. Impulse Control Disorders; ICD) can lead to various disorders that encompass drug addiction, pathological gambling, compulsive shopping, binge eating, hypersexuality. In the past years, the role of the subthalamic nucleus (STN) in impulsivity has been highlighted. The STN is the current target for the surgical treatment of Parkinson's Disease using Deep Brain Stimulation (DBS). Interestingly, PD is a disease often associated with ICD. The aim of the present project is thus to characterise the effects of STN DBS in various forms of ICD in intact rats and assessed in various behavioural tasks measuring impulsive choice, gambling and addiction. The studies carried out in rats will be paralleled by clinical studies characterizing the effects of STN DBS applied in PD patients on ICD, measured in various tasks such as Go/NoGo and the Iowa gambling task. This project, bringing together experts in rat STN, impulsivity and clinical experts of STN DBS in patients, should lead to a better understanding of STN contribution in ICD processes and may also lead to a more refined prescription of STN DBS for the treatment of ICD.
Competitiondate
201006
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Winstanley, Catharine A; Baunez, Christelle; Rodriguez Oroz, Maria C
Approvedterm
3 ans 0 mois
Cihrcontribution2
Inst of Neurosc Mental Hlth &A~ $155,250~ $24,227~
