Grant: Project Grant
University of Toronto
$967,726.00
Evolution and function of long noncoding RNAs in the male reproductive system
FY 2018-19
Summary
Until recently it has been assumed that all genes encode proteins, and the numbers of these genes and their products are responsible for organism diversity. After the sequencing of many organism genomes, we now know that this is not true. What is proportional to organism diversity is the number of genes that do not encode proteins, called non-coding genes. We will study the most abundant of these called long non-coding RNA (lncRNA) genes. We will do so in the tissues where they are believed to have first evolved, the adult testes. Our genome-wide analysis will provide the information required to determine how these genes are evolving and how they regulate fertility and organism diversity.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
403801
Name
Krause Henry M
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Developmental Biology
Projecttitle
Evolution and function of long noncoding RNAs in the male reproductive system
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$967,726
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Exrnas; Fertility; Gene Expression; Lncrnas; Male Reproduction; Spermatogenesis
Abstract
Until recently it has been assumed that all genes encode proteins, and the numbers of these genes and their products are responsible for organism diversity. After the sequencing of many organism genomes, we now know that this is not true. What is proportional to organism diversity is the number of genes that do not encode proteins, called non-coding genes. We will study the most abundant of these called long non-coding RNA (lncRNA) genes. We will do so in the tissues where they are believed to have first evolved, the adult testes. Our genome-wide analysis will provide the information required to determine how these genes are evolving and how they regulate fertility and organism diversity.
Competitiondate
201903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Krause, Henry M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $967,726~ $0~
