Grant: Project Grant
McGill University
$1,147,500.00
The multifaceted role of c-Src tyrosine kinase in breast cancer progression.
FY 2022-23
Summary
The principal objective of this CIHR project is to elucidate the relative contribution of c-Src in breast cancer progression. The first aim of the proposal is directed towards understanding the role of FOXM1 transcription factor in c-Src dependent breast cancer progression. The second aim of the proposal will evaluate the role in c-Src/DRP-1 in modulating the metabolic state of breast cancer cells. Finally, we will identify potential vulnerabilities in c-Src dependent breast cancers and determine if these could be exploited therapeutically in different breast cancer subtypes.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
468470
Name
Muller William J
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Molecular & Cellular Biology of Cancer
Projecttitle
The multifaceted role of c-Src tyrosine kinase in breast cancer progression.
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$1,147,500
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Breast Cancer; C-Src; Drp-1; Foxm1; Genetic Engineered Mouse Models; Her2; Luminal B Subtype; Tyrosine Kinase
Abstract
The principal objective of this CIHR project is to elucidate the relative contribution of c-Src in breast cancer progression. The first aim of the proposal is directed towards understanding the role of FOXM1 transcription factor in c-Src dependent breast cancer progression. The second aim of the proposal will evaluate the role in c-Src/DRP-1 in modulating the metabolic state of breast cancer cells. Finally, we will identify potential vulnerabilities in c-Src dependent breast cancers and determine if these could be exploited therapeutically in different breast cancer subtypes.
Competitiondate
202209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Muller, William J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,147,500~ $0~
