Grant: Project Grant
Research Institute of the McGill University Health Centre
$344,250.00
Group B Streptococcus-induced placental infection and subsequent sex-dichotomous neurobehavioural impairments in the offspring: Investigating the role of interleukin-1 (IL-1)
FY 2018-19
Summary
Neonatal brain injury and subsequent brain disabilities are major public heath issue for which little effective preventive or therapeutic intervention is available. The research we did during the last years provided the first demonstration linking maternal immune activation triggered by microbes, placental and fetal inflammation associated to interleukin-1 (an inflammatory mediator), and sex-differentiated newborn brain injury leading to autism in male and attention deficit and hyperactivity in female. These results pave the way for: 1) the study of the role of sexual hormones in modulating maternofetal inflammation; 2) new anti-inflammatory treatments using interleukin-1 blockers to prevent neurological threats arising from perinatal inflammation. However, further pre-clinical evaluation of efficacy and safety of interleukin-1 blockers, as presented in this proposal, are still needed before launching human therapeutic trials.
Department
Program
Project Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
402351
Name
Sebire Guillaume
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Clinical Investigation - A: Reproduction, Maternal, Child and Youth Health
Projecttitle
Group B Streptococcus-induced placental infection and subsequent sex-dichotomous neurobehavioural impairments in the offspring: Investigating the role of interleukin-1 (IL-1)
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$344,250
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Development; Infectious Disease; Neuroscience; Placenta; Sex
Abstract
Neonatal brain injury and subsequent brain disabilities are major public heath issue for which little effective preventive or therapeutic intervention is available. The research we did during the last years provided the first demonstration linking maternal immune activation triggered by microbes, placental and fetal inflammation associated to interleukin-1 (an inflammatory mediator), and sex-differentiated newborn brain injury leading to autism in male and attention deficit and hyperactivity in female. These results pave the way for: 1) the study of the role of sexual hormones in modulating maternofetal inflammation; 2) new anti-inflammatory treatments using interleukin-1 blockers to prevent neurological threats arising from perinatal inflammation. However, further pre-clinical evaluation of efficacy and safety of interleukin-1 blockers, as presented in this proposal, are still needed before launching human therapeutic trials.
Competitiondate
201903
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Sebire, Guillaume
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $344,250~ $0~
