Grant: Project Grant
Université de Sherbrooke
$841,500.00
Systematic identification of synthetic interactions in bacteria towards the next-generation of antibiotics
FY 2022-23
Summary
The rapid rise in antibiotic resistance is accelerating our need to find new antibiotics with novel mechanisms of action. Current antibiotics target a limited number of bacterial processes that are performed by the product of essential genes. However, the cell is an elaborate network of genetic interactions, and many of these interactions are also essential for the cell but are not currently exploited as antibacterial strategies. Here, we will establish the complete network of genetic interactions in the model bacterium Escherichia coli, and use this knowledge to develop novel antibacterial strategies. This project will thus constitute an invaluable resource to better understand bacterial cell physiology while laying the foundations of an original platform for antibiotic discovery.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
468567
Name
Côté Jean-Philippe
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Genomics: Systems and computational biology
Projecttitle
Systematic identification of synthetic interactions in bacteria towards the next-generation of antibiotics
Programtype2
Operating Grants
Orgnameinp2
Université de Sherbrooke
Cihramount2
$841,500
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Antibiotic Discovery; Bacteriology; Combination Therapy; Genetic Interactions; High-Density Transposon Mutagenesis; Systems Biology
Abstract
The rapid rise in antibiotic resistance is accelerating our need to find new antibiotics with novel mechanisms of action. Current antibiotics target a limited number of bacterial processes that are performed by the product of essential genes. However, the cell is an elaborate network of genetic interactions, and many of these interactions are also essential for the cell but are not currently exploited as antibacterial strategies. Here, we will establish the complete network of genetic interactions in the model bacterium Escherichia coli, and use this knowledge to develop novel antibacterial strategies. This project will thus constitute an invaluable resource to better understand bacterial cell physiology while laying the foundations of an original platform for antibiotic discovery.
Competitiondate
202209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Côté, Jean-Philippe
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $841,500~ $0~
