Grant: Alliance Grants

Our project aims to develop a non-invasive method that can correlate highly with invasive arterial and venous pressure measurements. Our Japanese collaborators from Kyoto, Kagoshima and Tsukuba Universities demonstrated that Cardiopulmonary Resuscitation (CPR) prognosis may improve when arterial pressure exceeds venous pressure. Thus, the current one-size-fits-all CPR approach necessitates individualized CPR tailored to each patient's needs. However, monitoring arterial and venous pressures is currently highly invasive, conducted via inserting catheters in blood vessels, preventing them from being used in Emergency Care settings. In this study, we aim to develop a novel non-invasive hemodynamic monitoring system for CPR guidance based on optical technology of measurements and monitoring of arterial and venous pulse wave shape and transient time. This proposed technique is based on novel, highly original, non-invasive carotid and venous blood flow monitoring techniques developed by the Toronto Metropolitan University (TMU) Photonics team. The international partnership combines the technical expertise of TMU Photonics with the Japanese team's unique expertise in cardiac arrest research. This collaborative study will enhance patient outcomes through personalized CPR strategies and substantially benefit Canada by saving lives and improving patients' quality of life and social reintegration rate, thus reducing the Health and Social Care burden.