Grant: Operating Grant
Université Laval
$819,840.00
Optimizing antiviral drug therapy and vaccines for influenza viruses
FY 2010-11
Summary
Imfluenza viruses constitute a serious threat to mankind through yearly epidemics affecting 10-20% of the Canadian population and occasional pandemics as shown by the rapid spread of the pandemic 2009 H1N1 virus throughout the world. Besides public health measures, antivirals and vaccines are the only specific modalities that have shown benefits in decreasing the number and/or the severity of influenza infections. However, antiviral drug resistance and suboptimal immune response limit the efficacy of these modalities. In this research proposal, we seek to optimize both antiviral treatment through a better knowledge of the mechanisms of drug resistance as well as current inactivated influenza vaccines by assessing new adjuvants and routes of administration.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
209606
Name
Boivin Guy
Region
Québec
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Optimizing antiviral drug therapy and vaccines for influenza viruses
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$819,840
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Adjuvant; Animal Model; Antiviral; Immunogenicity; Influenza; Mathematical Model; Neuraminidase Inhibitor; Resistance; Reverse Genetics; Vaccine
Abstract
Imfluenza viruses constitute a serious threat to mankind through yearly epidemics affecting 10-20% of the Canadian population and occasional pandemics as shown by the rapid spread of the pandemic 2009 H1N1 virus throughout the world. Besides public health measures, antivirals and vaccines are the only specific modalities that have shown benefits in decreasing the number and/or the severity of influenza infections. However, antiviral drug resistance and suboptimal immune response limit the efficacy of these modalities. In this research proposal, we seek to optimize both antiviral treatment through a better knowledge of the mechanisms of drug resistance as well as current inactivated influenza vaccines by assessing new adjuvants and routes of administration.
Competitiondate
201009
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Boivin, Guy
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $819,840~ $0~
