Grant: Operating Grant
University of British Columbia
$660,000.00
Regulation of cell migration by a Rap1 GTPase-dependent sensor of extracellular matrix density that controls cytoskeletal and focal adhesion dynamics.
FY 2009-10
Summary
The ability of cells to move within the body, which requires them to attach to and pull themselves along a web of matrix proteins, is a highly regulated component of tissue and organ development. When cancers metastasize, this process is co-opted such that tumor cells move abnormally from the tissue of origin (ie. breast or prostate) to distant sites (ie. bone or brain) during the terminal endstages of the disease. We have recently determined that a cell's ability to sense the number of attachment proteins present in the matrix web is a key regulator of cell migration and metastasis. Therefore, this project has been designed to identify the key molecular components of this 'sensor' such that new therapeutic strategies can be developed to prevent metastatic spread by overriding it.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
201124
Name
Roskelley Calvin D
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cell Biology & Mechanisms of Disease
Projecttitle
Regulation of cell migration by a Rap1 GTPase-dependent sensor of extracellular matrix density that controls cytoskeletal and focal adhesion dynamics.
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$660,000
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cell Adhesion; Cell Migration; Cytoskeleton; Intravital Imaging; Live Cell Imaging; Protein-Protein Interaction
Abstract
The ability of cells to move within the body, which requires them to attach to and pull themselves along a web of matrix proteins, is a highly regulated component of tissue and organ development. When cancers metastasize, this process is co-opted such that tumor cells move abnormally from the tissue of origin (ie. breast or prostate) to distant sites (ie. bone or brain) during the terminal endstages of the disease. We have recently determined that a cell's ability to sense the number of attachment proteins present in the matrix web is a key regulator of cell migration and metastasis. Therefore, this project has been designed to identify the key molecular components of this 'sensor' such that new therapeutic strategies can be developed to prevent metastatic spread by overriding it.
Competitiondate
201003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Roskelley, Calvin D; Gold, Michael R
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $660,000~ $0~
