Grant: Operating Grant
McGill University
$613,554.00
Embryonic stress response as a determinant of developmental toxicity
FY 2009-10
Summary
Many drugs and environmental toxicants induce a stress response. The embryo is uniquely sensitive to insult during the time when organs are developing. We hypothesize that the ability of the embryo to respond to stress is an important determinant of developmental outcome. Furthermore, we suggest that there are specific signaling pathways which are uniquely sensitive to stress and mediate this response. Elucidation of the role that these signalling pathways play in protecting the embryo against insult will permit us to develop new strategies to prevent birth defects.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
199580
Name
Hales Barbara F
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Pharmaceutical Sciences
Projecttitle
Embryonic stress response as a determinant of developmental toxicity
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$613,554
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Adverse Effects Of Drugs; Birth Defects; Developmental Toxicology; Stress Response; Teratogen
Abstract
Many drugs and environmental toxicants induce a stress response. The embryo is uniquely sensitive to insult during the time when organs are developing. We hypothesize that the ability of the embryo to respond to stress is an important determinant of developmental outcome. Furthermore, we suggest that there are specific signaling pathways which are uniquely sensitive to stress and mediate this response. Elucidation of the role that these signalling pathways play in protecting the embryo against insult will permit us to develop new strategies to prevent birth defects.
Competitiondate
201003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Hales, Barbara F
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $613,554~ $0~
