Grant: Operating Grant - E-Rare-2 Joint Transnational Call on Rare Diseases
Ottawa Hospital Research Institute
$155,599.00
An international effort to understand FSHD muscular dystrophy epigenetics
FY 2013-14
Summary
Members of our research team have previously identified that a long, non-protein coding RNA (termed DBE-T) that is expressed from the disease locus in FSHD patients, but not the general population. Evidence suggests that the expression of this RNA in muscle cells leads to epigenetic changes that turns on multiple genes involved in development of FSHD. In this proposal, we will examine the role of DBE-T in the manifestation of the disease, and the mechanism through which it acts to disrupt normal muscle function. Completion of this work will facilitate the development of novel therapies that will allow for the treatment of FSHD.
Department
Program
Operating Grant - E-Rare-2 Joint Transnational Call on Rare Diseases
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
288520
Name
Dilworth Jeffrey J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Muscular Dystrophy Canada (Toronto, Ontario); The French National Research Agency (France); Ministero della Salute (Italy)
Instname2
Genetics
Theme2
Biomedical
Prcname2
Special Cases
Projecttitle
An international effort to understand FSHD muscular dystrophy epigenetics
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$155,599
Cihrequipment2
$0
Programname2
Operating Grant - E-Rare-2 Joint Transnational Call on Rare Diseases
Keyworddelim
Chromatin; Epigenetic; Facioscapulohumeral Muscular Dystrophy; Genome-Wide Rnai; Non Protein-Coding Rna; Pathophysiology
Abstract
Members of our research team have previously identified that a long, non-protein coding RNA (termed DBE-T) that is expressed from the disease locus in FSHD patients, but not the general population. Evidence suggests that the expression of this RNA in muscle cells leads to epigenetic changes that turns on multiple genes involved in development of FSHD. In this proposal, we will examine the role of DBE-T in the manifestation of the disease, and the mechanism through which it acts to disrupt normal muscle function. Completion of this work will facilitate the development of novel therapies that will allow for the treatment of FSHD.
Competitiondate
201305
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Dilworth, Jeffrey J
Approvedterm
3 ans 0 mois
Cihrcontribution2
Institute of Genetics~ $155,599~ $0~
