Grant: Operating Grant
University of Toronto
$914,636.00
Design and Application of Combinatorial Libraries of Synthetic Antibodies and Alternative Scaffolds
FY 2013-14
Summary
Protein-protein interactions are involved in essentially all biological processes. Furthermore, most diseases are caused by or are associated with aberrant protein-protein interactions. Thus, understanding and manipulating protein-protein interactions holds great potential for enhancing our understanding of how cells work, and also, for developing therapies for devastating diseases such as cancer and infectious disease. This project will develop libraries of synthetically-produced antibodies as a source of molecules to selectively form a complex with proteins inside cells. These antibodies will be invaluable tools for probing cell function and could even be used as therapies for unmet medical needs.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
304790
Name
Sidhu Sachdev S
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Design and Application of Combinatorial Libraries of Synthetic Antibodies and Alternative Scaffolds
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$914,636
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Affinity Reagents; Combinatorial Libraries; Diagnostics; High Throughput Screening; Molecular Targeting; Phage Display; Protein-Protein Interactions; Synthetic Antibodies; Therapeutics
Abstract
Protein-protein interactions are involved in essentially all biological processes. Furthermore, most diseases are caused by or are associated with aberrant protein-protein interactions. Thus, understanding and manipulating protein-protein interactions holds great potential for enhancing our understanding of how cells work, and also, for developing therapies for devastating diseases such as cancer and infectious disease. This project will develop libraries of synthetically-produced antibodies as a source of molecules to selectively form a complex with proteins inside cells. These antibodies will be invaluable tools for probing cell function and could even be used as therapies for unmet medical needs.
Competitiondate
201403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sidhu, Sachdev S
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $914,636~ $0~
