Grant: Operating Grant - Priority Announcement: Blood Utilization and Conservation
University of Toronto
$0.00
Design and Implementation of Circulatory Oxygen Therapeutics Derived from Human Hemoglobin by Improved Systematic Chemical Coupling and Cross-Linking
FY 2013-14
Summary
Blood collected for transfusions expires after 42 days of refrigerated storage. The oxygen-carrying component inside the cell is hemoglobin, which retains its potential utility. The proposed research will develop efficient processes to convert the recovered hemoglobin into a safe and effective material that can be used in place of red cells in transfusions and for drug delviery in circuiation. The research will develop chemical methods that convert hemogobin into a stable and effective oxygen carrier that is tested for safety and efficacy. The work is based on the principles of development of pharmaceuticals in which chemicals are improved based on the information obtained from the effects of specific materials. Those effects will be tested in an effective animal model by our collaborator at Harvard Medical School who is an expert in the effects that result from administration of red cell substitutes. The analysis of the materials will also include a detailed structural profile to define characteristics of safe and effective materials. The resulting materials will improve blood utilization as well as provide access to alternatives to whole blood in remote communities.
Department
Program
Operating Grant - Priority Announcement: Blood Utilization and Conservation
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
297778
Name
Kluger Ronald H
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Canadian Blood Services (Ottawa)
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Pharmaceutical Sciences
Projecttitle
Design and Implementation of Circulatory Oxygen Therapeutics Derived from Human Hemoglobin by Improved Systematic Chemical Coupling and Cross-Linking
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$0
Cihrequipment2
$0
Programname2
Operating Grant - Priority Announcement: Blood Utilization and Conservation
Keyworddelim
Avodiance Of Circulatory Stress; Avoidance Of Endothelial Nitric Oxide Scavenging; Circulating Oxygen Carrier; Coupling Of Hemoglobin And Protective Enzymes; Design For Minimizing Vasoactivity; Improved Specific Protein Modification; Specific Cross-Links In Hemoglobin; Sterile Oxygen Transport Solutions; Universal Red Cell Alternative; Use Of Materials From Expired Red Cells
Abstract
Blood collected for transfusions expires after 42 days of refrigerated storage. The oxygen-carrying component inside the cell is hemoglobin, which retains its potential utility. The proposed research will develop efficient processes to convert the recovered hemoglobin into a safe and effective material that can be used in place of red cells in transfusions and for drug delviery in circuiation. The research will develop chemical methods that convert hemogobin into a stable and effective oxygen carrier that is tested for safety and efficacy. The work is based on the principles of development of pharmaceuticals in which chemicals are improved based on the information obtained from the effects of specific materials. Those effects will be tested in an effective animal model by our collaborator at Harvard Medical School who is an expert in the effects that result from administration of red cell substitutes. The analysis of the materials will also include a detailed structural profile to define characteristics of safe and effective materials. The resulting materials will improve blood utilization as well as provide access to alternatives to whole blood in remote communities.
Competitiondate
201309
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Kluger, Ronald H
Approvedterm
3 ans 0 mois
