Grant: Team Grant: E-Rare Joint Transnational Call
University of Toronto
$301,551.00
Genomic Instability of Expanded Repeats in HD and ALS/FTD
FY 2018-19
Summary
Huntington Disease (HD) and certain forms of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) are inherited. Their genetic root cause is the expansion of short, repeated stretches of DNA, namely CAG repeats in the huntingtin gene for HD and GGGGCC (G4C2) repeats in the C9orf72 gene for ALS/FTD. These expansions are unstable and drive disease onset and progression. However, how and why certain cells in the brain become vulnerable to disease but others remain healthy is not understood. Here we apply novel technologies to solve the mystery of cell-specific repeat expansion toxicity in both model systems and human brain.
Department
Program
Team Grant: E-Rare Joint Transnational Call
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
395883
Name
Robertson Janice
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
German Federal Ministry of Research, Technology and Space (Berlin); The French National Research Agency (France); National Research, Development and Innovation Office (Budapest, Hungary); Ministero della Salute (Italy)
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Special Cases
Projecttitle
Genomic Instability of Expanded Repeats in HD and ALS/FTD
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$301,551
Cihrequipment2
$0
Programname2
Team Grant: E-Rare Joint Transnational Call
Keyworddelim
Amyotrophic Lateral Sclerosis; C9orf72; Expanded Repeats; Frontotemporal Dementia; Huntington'S Disease
Abstract
Huntington Disease (HD) and certain forms of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) are inherited. Their genetic root cause is the expansion of short, repeated stretches of DNA, namely CAG repeats in the huntingtin gene for HD and GGGGCC (G4C2) repeats in the C9orf72 gene for ALS/FTD. These expansions are unstable and drive disease onset and progression. However, how and why certain cells in the brain become vulnerable to disease but others remain healthy is not understood. Here we apply novel technologies to solve the mystery of cell-specific repeat expansion toxicity in both model systems and human brain.
Competitiondate
201806
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Robertson, Janice
Approvedterm
3 ans 0 mois
Cihrcontribution2
Institute of Genetics~ $301,551~ $0~
