Contribution: Industrial Research Assistance Program – Contributions to Firms
Willow Biosciences Inc.
$63,000.00
Pathway Refractoring for Scale up to Commercial Yields of Fermentation-based Synthetic Chemical Production
FY 2019-20 · 2019-04-01
Summary
The overall objective of this project is to generate an optimized, high-yielding, commercial-scale alkaloid production technology based on yeast fermentation using existing Epimeron IP and building on previous R&D such as NRC-IRAP Projects 834944 and 861555. Although previous work has established a small-scale system capable of turning over alkaloid product, the yields fall short of commercial level titers (e.g. >10g/L). This proposal aims to (i) address dominant problems with current yeast production strains and (ii) improve titers, using inexpensive starting materials, to reach commercially feasible levels. Collaboration with a fermentation-specialized partnering firm will enable technology development in a scaled-up context.
Department
Program
Industrial Research Assistance Program – Contributions to FirmsIndustrial Research Assistance Program-Contributions to Firms (linked with high confidence)
Recipient
Location
Calgary|Calgary, Alberta, Canada
Recipient Type
For-profit organization
Business Number
120025523
Type
Contribution
Source
Proactive Disclosure - Grants and Contributions
As published
Agreement End Date
2020-06-30
Agreement Number
938333
Agreement Start Date
2019-04-01
Agreement Title
Pathway Refractoring for Scale up to Commercial Yields of Fermentation-based Synthetic Chemical Production
Agreement Title (French)
Réfraction de la voie pour atteindre les rendements commerciaux de la production chimique synthétique à base de fermentation
Agreement Type
Contribution
Agreement Value
$63,000.00
Amendment Number
0
Coverage
IRAP Contributions to Firms projects stimulate wealth creation for Canada through technological innovation. | Les projets des Contributions aux entreprises stimulent la création de richesse au Canada grâce à l’innovation technologique.
Description
The overall objective of this project is to generate an optimized, high-yielding, commercial-scale alkaloid production technology based on yeast fermentation using existing Epimeron IP and building on previous R&D such as NRC-IRAP Projects 834944 and 861555. Although previous work has established a small-scale system capable of turning over alkaloid product, the yields fall short of commercial level titers (e.g. >10g/L). This proposal aims to (i) address dominant problems with current yeast production strains and (ii) improve titers, using inexpensive starting materials, to reach commercially feasible levels. Collaboration with a fermentation-specialized partnering firm will enable technology development in a scaled-up context.
Description (French)
L'objectif global de ce projet est de mettre au point une technologie de production d'alcaloïdes optimisée, à haut rendement et à l'échelle commerciale, basée sur la fermentation de levure en utilisant les plèvres IP actuelles et en tirant parti de la R-D précédente, comme les projets 834944 et 861555 du PARI-CNRC. Bien que des travaux antérieurs aient établi un système à petite échelle capable de retourner les produits alcaloïdes, les rendements n'atteignent pas le niveau de dosage commercial (p. ex., >10 g/L). Cette proposition vise à résoudre les problèmes dominants liés aux souches actuelles de production de levure et à améliorer les niveaux de dosage, et ce, en utilisant des matières premières peu coûteuses pour atteindre des niveaux commercialement atteignables. La collaboration avec une entreprise partenaire spécialisée dans la fermentation permettra le développement de technologies dans un contexte à plus grande échelle.
Expected Results
The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization
Expected Results (French)
Le PARI, par le biais des Contributions aux entreprises, vise à appuyer la recherche, le développement, l’adaptation et/ou l’adoption au Canada de produits, de services ou de processus novateurs ou axés sur des technologies nouvelles ou améliorées, et ce jusqu’à leur commercialisation
Federal Riding
Calgary Confederation
Federal Riding (French)
Calgary Confederation
Federal Riding Number
48005
NAICS Code
325410
Organization Code
nrc-cnrc
Organization
National Research Council Canada | Conseil national de recherches Canada
Program Name
Industrial Research Assistance Program – Contributions to Firms
Program Name (French)
Programme d’aide à la recherche industrielle – Contributions aux entreprises
Program Purpose
The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization
Program Purpose (French)
Le PARI, par le biais des Contributions aux entreprises, vise à appuyer la recherche, le développement, l’adaptation et/ou l’adoption au Canada de produits, de services ou de processus novateurs ou axés sur des technologies nouvelles ou améliorées, et ce jusqu’à leur commercialisation
Recipient Business Number
120025523
Recipient City
Calgary|Calgary
Recipient Country
CA
Recipient Legal Name
Willow Biosciences Inc.
Recipient Postal Code
T2L 1Y8
Recipient Province or Territory
AB
Recipient Type
F
Reference Number
172-2019-2020-Q3-938333
