Grant: Operating Grant
Research Institute of the McGill University Health Centre
$843,570.00
Subversion of Macrophage Signaling by the Protozoan Parasite Leishmania
FY 2010-11
Summary
The protozoan Leishmania is an intracellular pathogen that invade macrophages of its human host infecting worldwide between 10-15 million people with 400 000 new cases every year. Pathogens of this group can cause several clinical manifestations which varies from cutaneous and mucocutaneous lesions to visceral infections. Infection of macrophages by Leishmania parasite leads to the inhibition of several important phagocyte immune functions bringing about an ineffective immune response development toward this pathogen. We have reported that alteration of several macrophage signaling pathways by Leishmania are responsible for these functional inhibitions. In this project, we wish to discover the negative regulatory mechanisms used by Leishmania to dodge the host immune response.
Department
Program
Operating Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
209445
Name
Olivier Martin
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Microbiology & Infectious Diseases
Projecttitle
Subversion of Macrophage Signaling by the Protozoan Parasite Leishmania
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$843,570
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cell Signaling; Inflammation; Innate Immune Response; Interferon; Leishmania-Macrophage Interaction; Myeloid Related Protein S100a; Negative Regulatory Mechanism; Nod-Like Receptors; Pathogen Associated Molecular Patterns; Protein Tyrosine Phosphatases
Abstract
The protozoan Leishmania is an intracellular pathogen that invade macrophages of its human host infecting worldwide between 10-15 million people with 400 000 new cases every year. Pathogens of this group can cause several clinical manifestations which varies from cutaneous and mucocutaneous lesions to visceral infections. Infection of macrophages by Leishmania parasite leads to the inhibition of several important phagocyte immune functions bringing about an ineffective immune response development toward this pathogen. We have reported that alteration of several macrophage signaling pathways by Leishmania are responsible for these functional inhibitions. In this project, we wish to discover the negative regulatory mechanisms used by Leishmania to dodge the host immune response.
Competitiondate
201009
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Olivier, Martin
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $843,570~ $0~
