Grant: Operating Grant
Université de Montréal
$757,624.00
The role of LARP1 in the translation of growth-promoting mRNAs
FY 2014-15
Summary
Our lab has identified a protein termed LARP1 which appears to be upregulated in several types of tumors, including prostate cancer. We found that LARP1 specifically regulates the process of cellular growth, but the mechanisms by which LARP1 accomplishes this function is unknown. The main goals of the proposed studies are to understand how LARP1 promotes cell growth, and to determine the impact of inhibiting LARP1 function in prostate cancer. Findings from this study will help determine the therapeutic potential of targeting LARP1 in cancer.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
322872
Name
Roux Philippe
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Molecular & Cellular Biology of Cancer
Projecttitle
The role of LARP1 in the translation of growth-promoting mRNAs
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$757,624
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Ampk; Energy Stress; Larp1; Mouse Models; Mrna Translation; Mtor; Phosphorylation; Prostate Cancer; Protein Synthesis; Ribosome Biogenesis
Abstract
Our lab has identified a protein termed LARP1 which appears to be upregulated in several types of tumors, including prostate cancer. We found that LARP1 specifically regulates the process of cellular growth, but the mechanisms by which LARP1 accomplishes this function is unknown. The main goals of the proposed studies are to understand how LARP1 promotes cell growth, and to determine the impact of inhibiting LARP1 function in prostate cancer. Findings from this study will help determine the therapeutic potential of targeting LARP1 in cancer.
Competitiondate
201503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Roux, Philippe
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $757,624~ $0~
