Grant: CAG/CCFC/CIHR Summer Studentship for Research in Gastroenterology
University of Toronto
$3,000.00
Role of the intestinal epithelial insulin-like growth factor-1 receptor in the intestinal growth effects of glucagon-like peptide-2
FY 2008-09
Summary
We have previously shown that the intestinal growth factor GLP-2 requires the presence of the IGF-1 receptor somewhere in the whole body. We are now examining whether this receptor is required to be present in the intestinal cells that are directly involved in intestinal growth, the epithelial cells. This is being studied using a genetically-modified mouse model in which the receptor is specifically removed from the intestinal epithelial cells. The results of these studies will more clearly define the cellular mechanisms by which GLP-2 stimulates intestinal growth.
Department
Program
CAG/CCFC/CIHR Summer Studentship for Research in Gastroenterology
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
182318
Name
Trivedi Shivangi
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Canadian Association of Gastroenterology (Oakville, Ontario); Crohn's and Colitis Canada (Toronto, Ontario)
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
CIHR - INMD - CAG (Canadian Association of Gastroenterology) Partnership
Projecttitle
Role of the intestinal epithelial insulin-like growth factor-1 receptor in the intestinal growth effects of glucagon-like peptide-2
Programtype2
Summer Student Programs
Orgnameinp2
University of Toronto
Cihramount2
$3,000
Cihrequipment2
$0
Programname2
CAG/CCFC/CIHR Summer Studentship for Research in Gastroenterology
Keyworddelim
Glp-2; Growth; Igf-1 Receptor; Intestine; Knockout Mice
Abstract
We have previously shown that the intestinal growth factor GLP-2 requires the presence of the IGF-1 receptor somewhere in the whole body. We are now examining whether this receptor is required to be present in the intestinal cells that are directly involved in intestinal growth, the epithelial cells. This is being studied using a genetically-modified mouse model in which the receptor is specifically removed from the intestinal epithelial cells. The results of these studies will more clearly define the cellular mechanisms by which GLP-2 stimulates intestinal growth.
Competitiondate
200902
Approvedterm2
0 yr 4 mths
Pinamesdelim
Trivedi, Shivangi
Approvedterm
0 an 4 mois
Cihrcontribution2
Inst of Nutr Metabolism &Diab~ $3,000~ $0~
