Grant: Project Grant

Fetal alcohol spectrum disorder (FASD) is a disorder caused by prenatal alcohol exposure that affects 4% of individuals in Canada. People with FASD may have challenges in different areas, but one of the most common is executive function, which is required for impulse control, behavioral regulation, planning and execution of goals. Brain differences in specific areas (i.e. the frontal-striatal circuit) seem to be one reason for these challenges. However, we do not understand the mechanisms of these brain differences, nor how they are affected by other factors, such as early adversity. In this project, we will use advanced magnetic resonance imaging (MRI) techniques to better understand the mechanisms of brain differences underlying executive function in youth with FASD. We will also thoroughly investigate the role of age, sex/gender and early childhood environment on these relationships to help explain individual differences. This will ultimately help lead to more personalized and more effective treatment options.