Grant: Operating Grant

Complex signaling networks converge to regulate cell fate and cell behaviour to correctly pattern tissue and control organogenesis. In cancer, many of the cell signaling pathways that control of developmental systems become misregulated during tumour initiation and progression to the metastatic state. Loss of Hippo pathway control may be one of the earliest steps in the initiation of cancer. Indeed, most if not all breast cancers have bypassed the hippo pathway and thereby acquire pro-tumorigenic and metastatic properties. Thus, identifying and understanding mechanisms to re-engage the hippo pathway and turn-off these inappropriate proliferative and migratory signals could provide novel therapeutic approaches to overcome this aberrant activity.